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- Principal Investigator:
Peter Frappell
- Department of Zoology
- La Trobe University, Melbourne,
Australia
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- The laboratory is mainly concerned
with various aspects of the oxygen cascade and what effects body
size and environmental stress have on the various parameters
involved in the delivery of oxygen. The approach to all aspects of
research is comparative. Areas that are currently under
investigation include: the determinants of aerobic capacity in
varanid lizards; ecophysiology of Daphnia in particular
adaptation/acclimation to low oxygen levels; energetics in penguins
and gannets; energetics in aquaculture fish; hypoxic hypothermia and
the resetting of the thermal set-point in mammals; adaptation to
altitude; respiratory physiology of burrowing mammals; aspects of
metabolism and ventilation during development in marsupials; the
effects hypoxia and temperature may have on metabolism, ventilation
and oxygen transport, and the control of breathing. The laboratory
is well equipped, operates a field extension lab in association with
large outdoor enclosures and the Wildlife Reserve, has access to an
extensive animal house and maintains a number of animal colonies for
research purposes.
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- Graduate Research
opportunities in
ærp
- The laboratory has gained a reputation
as a productive and constructive environment. It functions as a
small community in which its members both contribute to its activity
and reap the benefits that it has to offer. The contributions
required are creative research, constructive criticism, and a
dedicated round-the-clock commitment. As for the benefits, the
laboratory has a good track record for attracting funding, offers
excellent facilities, maintains strong international collaborations
and provides a very friendly and pleasant working environment.
If you would like to join the laboratory as
a graduate student please contact me to discuss potential projects.
| People in our lab |
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- Postdocs
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- Graduate Students:
- Paul Wiggins
- Sarah Andrewartha
- Joanne Avraam
- Shannon Simpson
- Lyndal Horne
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- Honours Students:
- Jonas Haag
- Bonnie Ashley
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- Distinguished Visiting Professor
- Prof Pat Butler (Univ.
Birmingham UK)
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- Current Collaborators
- Dr
Andreas Moeller (Peter Mac Research Division)
- Dr Gary Cohen
(Univ. Sydney)
- Prof Roger Seymour (Univ.
Adelaide)
- Dr Tim Clark (Univ. British Columbia)
- Dr Peter Dann (Phillip Island Nature Park)
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- Recent Visitors
- Dr Lewis Halsey, Univ.
Birmingham UK, IAS sponsored Fellow May-Jul 2007
- Dr Kath Sloman, Univ.
Plymouth UK, IAS sponsored Fellow Jul-Aug 2008
- Elias Polymero, Univ.
Marburg, GER, DAAD Fellow Jun-Nov 2008.
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- Nick who
works with fish from Mildura
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- Lab Alumni
- Dr Peter MacFarlane (PhD), now Postdoc, Univ Wisconsin
- Dr Tim Clark (PhD), now Killam
Postdoc Fellow, UBC
- Dr Nicola Mitchell (Postdoc 2005), now
ARC Fellow, UWA
- Dr Kevin
Cummings (Postdoc 2006-2007), now postdoc, Dartmouth
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Dr
Jon Green (Postdoc 2006-2008), now Lecturer, Univ Liverpool,
UK
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- Current Funding
- FRDC, SeaWorld, various
contracts to private industry
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Recent publications from
ærp |
- Fish, F., Baudinette, R.V.,
Frappell, P.B. and Sarre, M. (1997). Energetics of swimming
in the platypus (Ornithorhynchus anatinus): metabolic
effort associated with rowing. J. exp. Biol. 200:
2647-2652.
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- Kukuk, P., Kilgore, D.L.
Jr., and Frappell P.B. (1997). Larval ejection behaviour in
Bombus occidentalis in response to CO2 or N2 induced
narcosis. J. Kansas Entomol. Soc. 70: 353-355.
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- Munns, S., Evans, B. and
Frappell, P.B. (1998). The effects of environmental
temperature, hypoxia, and hypercapnia on the breathing
pattern of saltwater crocodiles (Crocodylus porosus)
in water. Physiol. Zool. 71: 267-273.
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- Frappell, P.B. (1998).
Hypothermia and physiological control: the respiratory
system. Clin. Exper. Pharmacol. Physiol. 25: 159-164.
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- Frappell, P.B. and Mortola,
J.P (1998). Passive body movement and gas exchange in the
frilled lizard (Chlamydosaurus kingii) and goanna (Varanus
gouldii). J. exp. Biol. 201:2307-2311
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- Boggs, D.F., Frappell, P.B.
and Kilgore, D.L. Jr. (1998). Ventilatory, cardiovascular
and metabolic responses to hypoxia and hypercapnia in the
armadillo. Respir. Physiol. 113: 101-109.
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- Frappell, P.B., Boggs, D.F.
and Kilgore, D.L. Jr (1998). How stiff is the armadillo?: a
comparison with the allometrics of mammalian respiratory
mechanics. Respir. Physiol. 113: 111-122.
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- Frappell, P.B.,
Leon-Vellarde, F.., Aguero, L., and Mortola , J.P. (1998)
Response to cooling temperature in infants born at an
altitude of 4,300 meters. Amer. J. Respirat. Crit. Care
Med. 158: 1751-1756.
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- Mortola, J.P. and Frappell,
P.B. (1998). On the barometric method for measurements of
ventilation, and its use in small animals. Can. J.
Physiol. Pharmacol. Invited commentary 76: 937-944
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- Mortola, J.P. Leon-Vellarde,
F. Aguero, L. and Frappell, P.B. (1999). Heart rate
variability in 1-day-old infants born at 4330 m altitude.
Clin, Science. 96: 147-153.
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- Mortola, J.P., Frappell,
P.B. and Woolley, P.A. (1999). Breathing through the skin in
a new-born mammal. Scientific correspondence. [Letter]
Nature 397: 660.
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- Schultz, T.R., Christian,
K.A. and Frappell, P.B. (1999). Do lizards breathe through
their mouth while running? Exper. Biol. Online 4:
39-46.
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- Frappell, P.B. and Mortola,
J.P. (2000). Respiratory function in a newborn marsupial
with skin gas exchange. Respir. Physiol. 120: 35-45,
2000
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- Mortola, J.P. and Frappell,
P.B. (2000). Ventilatory response to temperature changes in
mammals and other vertebrates. Annu. Rev. Physiol.
62:847-74.
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- Mortola, J.P., Frappell,
P.B., Aquero, L. and Armstrong, K. (2000). Birth weight and
altitude: a study of peruvian communities. J. Pediatrics
136: 324-329.
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- Wiggins, P. R. and Frappell,
P.B. (2000). The effect of haemoglobin on behavioural
thermoregulation and oxygen consumption in Daphnia
carinata. Physiol. Biochem. Zool. 73: 153-160
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- Boggs, D.F. and Frappell,
P.B. (2000) Unifying principles of locomotion: forward.
Physiol. Biochem. Zool.73: 647–650
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- Baudinette, R.V. and
Frappell, P.B. (2001). Animals coping with environmental
stress. In: Biology, 2nd ed., Eds.
Ladiges, P., Evans, B. and Saint, R. Chapt 29, McGraw-Hill,
Syd.
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- Frappell, P.B. (2001). Gas
exchange and transport in animals. In: Biology, 2nd
ed., Eds. Ladiges, P., Evans, B. and Saint, R. Chapt 20,
McGraw-Hill, Syd.
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- Frappell, P.B., Boggs, D.F.
and Hinds, D.S. (2001). Scaling of respiratory variables and
the breathing pattern in birds: an allometric and
phylogenetic approach. Physiol. Biochem. Zool. 74:
75-89.
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- MacFarlane, P.M. and Frappell,
P.B. (2001). Convection requirement is established by total
metabolic rate in the newborn tammar wallaby. Respir.
Physiol. 126: 221-231.
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- Fish, F.E., Frappell, P.B.,
Baudinette, R.V, and MacFarlane, P.M.. (2001). Energetics of
terrestrial locomotion of the platypus Ornithorhynchus
anatinus. J. Exp. Biol. 204(4):797-803.
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- Maskrey, M., Frappell, P.B.
and Wiggins, P.R. (2001). Behavioral thermoregulation in
obese and lean zucker rats in a thermal gradient. Am.
J. Physiol. 281: R1675-R1680.
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- Boggs, D.F., Baudinette, R.V.,
Frappell, P.B. and Butler, P.J. (2001) The influence of
locomotion on air-sac pressures in little penguins. J.
Exp. Biol. 204, 3581–3586.
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- MacFarlane, P.M., Frappell,
P.B. and Mortola, J.P. (2002).
Mechanics of the
respiratory system in the newborn tammar wallaby. J.
Exp. Biol. 205: 533-538.
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Frappell, P.B., Baudinette, R.V., MacFarlane, P.M., Wiggins,
P.R. and Shimmin, G. (2002). Ventilation and metabolism in a
large semi-fossorial marsupial: the effect of graded hypoxia
and hypercapnia Physiol. Biochem. Zool. 75: 77-82.
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- Butler, P.J., Frappell, P.B.,
Wang, T. and Wikelski, M. (2002). The relationship between
heart rate and rate of oxygen consumption in Galapagos
marine iguanas (Amblyrhynchus cristatus) at two
different temperatures J. Exp. Biol. 205:
1917-1924.
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- Frappell, P.B., Schultz, T.J.
and Christian, K.A. (2002). Oxygen
transfer during aerobic exercise in a varanid lizard
Varanus mertensi is limited by the circulation. J.Exp.
Biol. 205: 2725-2736.
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- Frappell, P.B., Schultz,
T.J. and Christian, K.A. (2002). The respiratory system in
varanid lizards: determinants of O2
transfer. Comp. Biochem. Physiol. 133A: 239-258.
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- Wiggins, P.R. and Frappell,
P.B. (2002). Behavioural thermoregulation in Daphnia
carinata from different depths of a natural water body:
influence of environmental oxygen levels and temperature.
Comp. Biochem. Physiol. 133A: 771-780.
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- Frappell, P.B. (2003).
Ventilation and metabolic rate in the platypus: insights
into the evolution of the mammalian breathing pattern.
Comp. Biochem. and Physiol. Part A. 136: 943-955.
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- Nakayama,
K., Frew, I.J., Hagensen, M., Skals, M., Habelhah, H.,
Erdjument-Bromage, H., Tempst, P., Frappell, P.B., Bowtell,
D.D., and Ronai, Z. (2004). Siah2 regulates stability of
prolyl-hydroxylases, controls HIF1a abundance and modulates
physiological responses to hypoxia. Cell. 117: 1–20.
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- Frappell, P.B. and Butler, P.J. (2004).
Minimal metabolic rate, what it is, its usefulness, and its
relationship to the evolution of endothermy: a brief
synopsis. Invited Perspectives. Physiol. Biochem. Zool.
in press
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Richardson, S.J. , Monk, J.A., Shepherdley, C.A., Ebbesson,
L.O.E., Sin, F., Power, D.M., Frappell, P.B., Ko¨hrle, J. ,
and Renfree, M.B. (2005). Developmentally regulated thyroid
hormone distributor proteins in marsupials, a reptile, and
fish. Am J Physiol Regul Integr Comp Physiol 288:
R1264–R1272.
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- Clark, T.D., Wang. T., Butler, P.J. and
Frappell. P.B. (2005). Factorial scopes of cardio-metabolic
variables remain constant with changes in body temperature
in the varanid lizard, Varanus rosenbergi. Am J
Physiol Regul Integr Comp Physiol 288: R992–R997.
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Clark,
T.D., Ryan, T., Ingram, B.A., Woakes, A.J., Butler, P.J.,
and Frappell, P.B. (2005). Factorial aerobic scope is
independent of temperature and primarily modulated by heart
rate in exercising Murray Cod. Physiological
and Biochemical Zoology
78(3):347–355.
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- Clark,
T.D., Butler, P.J., and Frappell, P.B. (2005).
Digestive state influences the heart rate
hysteresis and rates of heat exchange in
the varanid lizard Varanus rosenbergi. J. Exp.
Biol. 208: 2269-2276.
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- Frappell, P.B. and MacFarlane, P.M.
(2005). Development of mechanics and pulmonary reflexes.
Respir. Physiol. Neurobiol.
149: 143-154.
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- Clark. T.D., Butler, P.J. and
Frappell P.B.
(2006) Factors influencing the
prediction of metabolic rate in a reptile.
Funct. Ecol.
20:105-113.
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Green, J.A., Frappell, P.B.,
Clark, T.D. & Butler, P.J. (2006) Physiological response to
feeding in little penguins. Physiological and Biochemical
Zoology 79(6) 1088-1097
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- Frappell, P.B. and MacFarlane, P.M.
(2006). Development of the respiratory system in marsupials.
Respir. Physiol. Neurobiol. 154: 252-267.
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- Green, J.A. and Frappell, P.B. (2007)
Improving the accuracy and precision for estimating energy
expenditure using the heart rate method. Physiol. Biochem. Zool.
80:551-555
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- Frappell, P.B.
León-Velarde, F. and Rivera-Ch, M. (2007).
Introduction: Oxygen Transport at High Altitude - An
Integrated Perspective. Respir.
Physiol. & Neurobiol. 158: 115-120
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Jastroch, M., Withers,
K.W., Taudien, S., Frappell,
P.B., Helwig, M., Fromme,
T., Hirschberg, V., Heldmaier,
G., McAllan, B. M.,
Firth, B. T., Burmester,
T., Platzer, M. and Klingenspor, M.
(2008). Marsupial uncoupling
protein 1 sheds light on the evolution of mammalian
nonshivering thermogenesis. Physiol Genomics
32:161-169.
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Frappell, P.B. (2008).
Ontogeny and allometry of metabolic
rate and ventilation in the marsupial: Matching supply and
demand from ectothermy to endothermy, Comparative
Biochemistry and Physiology 150: 181-188.
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Green, J.A., Frappell, P.B.,
Clark, T.D. and Butler, P.J. (in press).
Predicting rate of oxygen consumption from
heart rate while little penguins work, rest and play.
Comparative Biochemistry and Physiology (2008), doi:
10.1016/j.cbpa.2006.06.017
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- Halsey, L.G., Green, J.A., Wilson, R.P.,
Frappell, P.B. (in press). Accelerometry to estimate
energy expenditure during activity: best practice with data
loggers. Physiol. Biochem. Zool.
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- Clark, T.D.,
Seymour, R.S., Wells, R.M.G., and Frappell, P.B. (2008).
Thermal effects on the blood respiratory properties of
southern bluefin tuna, Thunnus
maccoyii. Comparative
Biochemistry and Physiology 150: 239-246.
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Begg, D.P., Mathai, M.L., McKinley, M.J.,
Frappell, P.B. and Kent, S. (2008). Central nitric oxide
synthase inhibition restores behaviorally mediated
lipopolysaccharide induced fever in near-term rats.
Physiology & Behavior 94: 630–634.
doi:10.1016/j.physbeh.2008.03.022
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